Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring

This study presents the development and evaluation of a non-invasive glucose monitoring device based on critical-depth Raman (CD-Raman) spectroscopy. The system measures glucose in the interstitial fluid at a specific depth beneath the skin, optimizing signal quality while minimizing interference from surrounding tissue. In a home-based clinical study, 35 individuals with diabetes used the device over a 60-day period, performing measurements independently without supervision or frequent recalibration. The results were compared to standard capillary blood glucose measurements, demonstrating good agreement and performance comparable to existing continuous glucose monitoring systems. The calibration remained stable for more than 10 days, highlighting the system’s suitability for real-life use. These findings demonstrate the feasibility of Raman spectroscopy as a practical, non-invasive solution for glucose monitoring in everyday diabetes management.