PUBLICATION IN NATURE SCIENTIFIC REPORTS “Calibration and performance of a Raman-based device for non-invasive glucose monitoring in type 2 diabetes”

A Raman-based non-invasive glucose monitor can achieve accurate measurements with only a short calibration period using a pre-trained model.

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Glucose Detectability & System Requirements

The first studies targeting non-invasive detection of glucose-related Raman signals were conducted in clinical settings and relied on operator-guided measurements. These early efforts informed the development of subsequent prototype generations, leading to a more compact, user-operated, and highly modular system designed for long-term data collection in home-use settings, enabling iterative optical improvements and more robust model development.

Optical Architecture & Measurement Site optimization

A highly modular prototype platform was developed and iteratively refined with a focus on home-use applicability. These studies used more compact, modular systems that could be tested in outpatient settings. Improvements to the optical design, including the introduction of a high-throughput confocal filtering approach, were evaluated. In addition, selection of the thenar measurement site enabled clearer and more reliable detection of glucose-related Raman signals.

Optical Platform Consolidation

Confirmed that Raman measurements can track physiologically meaningful glucose dynamics and that a well-defined optical core (derived from the previous prototype) could be transferred into a compact unit without loss of performance.

Calibration Stability & Real-Life Performance

Demonstrated that calibration models remain stable during extended real-life use and, through direct generation-to-generation comparison. It also showed that newer device designs outperform earlier ones under identical conditions. Started therefore building an improved system suitable for portable use.

Performance, Safety & Usability validation of a compact production ready device

Together, these studies validated a fully independent, portable, and integrated device in real-life use, demonstrating reliable field performance at scale. The results confirmed technical robustness, usability, safety, and practical calibration across large and diverse populations, with approximately 160 devices tested by 160 participants.

Algorithm refinement

These studies focused on algorithm refinement, evaluating a new calibration approach designed to minimize calibration requirements. Whereas earlier studies required calibration periods of three to four weeks, this work demonstrated that effective calibration could be achieved within only a few hours, representing a significant practical improvement.

Next generation product

RSP-24-4 was a fundamental research study that investigated the minimum spectral resolution required to reliably capture glucose-related Raman information, providing design constraints for future optical system optimization.

Research publications

Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring

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May 11, 2018

3. Optical Platform Consolidation

PUBLICATION IN NATURE SCIENTIFIC REPORTS “Calibration and performance of a Raman-based device for non-invasive glucose monitoring in type 2 diabetes”

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March 25, 2025

4. Calibration Stability & Real-Life Performance

Accurate Post-Calibration Predictions for Noninvasive Glucose Measurements in People Using Confocal Raman Spectroscopy

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March 6, 2023

5. Performance, Safety & Usability validation of a compact production ready device

Research studies

An explorative, nonrandomized, openlabel, inclinic study investigating the performance of a novel noninvasive glucose monitoring device using a new guided calibration method (RSP-26)

January 1, 2020

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6. Algorithm refinement

An explorative study of a novel noninvasive glucose measuring device in outpatient settings (RSP-24)

January 1, 2020

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5. Performance, Safety & Usability validation of a compact production ready device

Performance and safety evaluation of a novel noninvasive glucose monitoring device and evaluation of the instructions for use (RSP-21)

January 1, 2020

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5. Performance, Safety & Usability validation of a compact production ready device

An explorative study of a novel noninvasive glucose monitoring device (RSP-19)

January 1, 2020

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5. Performance, Safety & Usability validation of a compact production ready device

Calibration of a noninvasive glucose measurement device and assessment of its performance in the hypoglycaemic range in patients with type 1 diabetes (RSP-17)

January 1, 2020

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4. Calibration Stability & Real-Life Performance

Performance characteristics of non-invasive glucose monitoring device prototypes (RSP-16)

January 1, 2020

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4. Calibration Stability & Real-Life Performance

Comparative study between two models of a non-invasive glucose monitoring device (RSP-14)

January 1, 2020

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4. Calibration Stability & Real-Life Performance

Performance study of a non-invasive glucose monitoring device prototype (RSP-13)

January 1, 2020

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4. Calibration Stability & Real-Life Performance

Performance characteristics and safety assessment of a non-invasive glucose monitoring device (RSP-12)

January 1, 2020

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4. Calibration Stability & Real-Life Performance

Database and calibration of a non-invasive glucose monitoring device (RSP-10)

January 1, 2020

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4. Calibration Stability & Real-Life Performance

Non-invasive glucose measurement with Raman technology. Calibration of newly developed devices in subjects with type 1 and type 2 diabetes – Glucobrunn study (RSP-09)

January 1, 2020

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3. Optical Platform Consolidation

Performance evaluation of a novel non-invasive glucometer, calibrated against validated interstitial glucose references (RSP-08)

January 1, 2020

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2. Optical Architecture & Measurement Site optimization

Non-invasive glucose measurements – database and calibration building (RSP-07)

January 1, 2020

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2. Optical Architecture & Measurement Site optimization

Non-invasive glucose measurements – database and calibration compilation (RSP-06)

January 1, 2020

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2. Optical Architecture & Measurement Site optimization

Non-invasive glucose measurements – database and calibration compilation (RSP-05)

January 1, 2020

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2. Optical Architecture & Measurement Site optimization

Non-invasive glucose measurements – database and calibration compilation (RSP-04)

January 1, 2020

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1. Glucose Detectability & System Requirements

Non-invasive glucose measurements – database and calibration compilation (RSP-03)

January 1, 2020

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1. Glucose Detectability & System Requirements

Non-invasive glucose measurements – database and calibration compilation (RSP-02)

January 1, 2020

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1. Glucose Detectability & System Requirements

Non-invasive glucose measurements – database and calibration compilation (RSP-01)

January 1, 2020

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1. Glucose Detectability & System Requirements

Posters

Orange blush

NON-INVASIVE GLUCOSE MONITORING BY A RAMAN SPECTROSCOPY-BASED PROTOTYPE AFTER MEAL CHALLENGE IN TYPE 1 DIABETES

February 19, 2020

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4. Calibration Stability & Real-Life Performance

Blue deep

Calibration of a non-invasive Raman spectroscopy device realized using pre-collected clinical data

March 11, 2024

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6. Algorithm refinement