NON-INVASIVE GLUCOSE MONITORING BY A RAMAN SPECTROSCOPY-BASED PROTOTYPE AFTER MEAL CHALLENGE IN TYPE 1 DIABETES

This study evaluates Raman spectroscopy as a method for non-invasive glucose monitoring by comparing a prototype device with standard blood glucose monitoring (BGM) and intermittent continuous glucose monitoring (iscCGM). Fifteen participants with type 1 diabetes underwent a carbohydrate-rich meal test, with measurements taken every 15 minutes over 450 minutes.

The results show that mean glucose values from the three methods were in good agreement, particularly during periods of low glucose variability. The non-invasive method demonstrated slightly lower rates of change compared to the reference methods.

Overall, the findings suggest that Raman-based non-invasive glucose monitoring can provide reliable average glucose measurements, supporting its potential as an alternative to existing monitoring technologies.